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Rickettsia africae sp. nov., the etiological agent of African tick bite fever.
Kelly PJ, Beati L, Mason PR, Matthewman LA, Roux V, Raoult D.
Department of Clinical Veterinary Studies, University of Zimbabwe, Harare.
We propose the name Rickettsia africae sp. nov. (with type strain Z9-Hu) for a distinct species of spotted fever group (SFG) rickettsiae that is the etiological agent of African tick bite fever in humans. This rickettsia has a distinct natural cycle and can be phenotypically distinguished from the other SFG rickettsiae by microimmunofluorescence serotyping, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and by Western blotting (immunoblotting). Genotypic differences between R. africae and the other SFG rickettsiae can be demonstrated by PCR restriction fragment length polymorphism analysis, pulsed-field gel electrophoresis, and sequencing of the 16S rRNA gene.
PMID: 8934912 [PubMed - indexed for MEDLINE]